hcv infection treatment: a future full of hope
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HCV infection treatment: a future full of hope
It is not more than 22 years that non A – non B hepatitis virus was discovered and cloned as a positive stranded enveloped RNA virus belonging to the flavivirus family named Hepatitis C Virus (1). Shortly after, it was known that like other hepatotropic virus it could have different genotypes with significant nucleotide sequence variability. HCV infection is a major public health problem infect...
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Abstract: Over the past few decades, the race against the treatment strategies of infectious HCV has gained a lot of momentum. These treatments include several therapies like Ribavirin, INF-α, DAA based pro-drugs, vaccines, and even naturally occurring compounds like herbal extracts as well as scorpion venom. All of these drugs have their specialized techniques and methodologies of administrati...
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The development of direct acting antiviral agents against the hepatitis C virus has revolutionized treatment paradigms for hepatitis C. In 2011 the first HCV protease inhibitors boceprevir and telaprevir were approved, which still needed to be combined with pegylated interferon and ribavirin and were only usable in patients with genotype 1. However, the new triple therapy achieved successful cu...
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Aim of antiviral therapy of patients with chronic hepatitis C is the sustained elimination of the hepatitis C virus (HCV). The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 or 2/3, respectively. Overall, approximately half of the patients can be cured by SOC. Based on baseline viral load and the speed of viro...
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BACKGROUND The stability and propagation of hepatitis C virus (HCV) is dependent on a functional interaction between the HCV genome and liver-expressed microRNA-122 (miR-122). Miravirsen is a locked nucleic acid-modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable heteroduplex, thereby inhibiting its function. METHODS In this phase 2a study...
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Hepatists C Virus is a RNA virus belonging to the Fl aviriridae family. It has been seen in previous studies that HCV infection perse is associated with reduced ovarian reserve and higher cycle cancellation rate in ovarian cycles. Simultaneously treatment of HCV with Pegylated Interferon (PEG-IFN) and ribavirin (RBV) is known to affect the ovarian reserve. Although there are some controversial ...
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عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۶، شماره ۱، صفحات ۲۰۱۳-۶
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